82 research outputs found
Prevalencia de la Neoplasia Intraepitelial de Vulva en pacientes que acuden a la Clínica de Displasias del Hospital Materno Infantil del ISSEMYM, del 01 de marzo del 2009 al 28 de febrero del 2013
Get PDFLa industria del ácido sulfúrico: Estrategias alternativas para la enseñanza y el aprendizaje de Química (Parte I)
Get PDFTomando como ejemplo la industria del ácido sulfúrico se pretende utilizar la riqueza temática desde el punto esencialmente químico, sino además todo lo que involucra una industria
desde el punto de vista social, económico y ambiental para un país
Diamond Thermal Expansion Measurement Using Transmitted X-ray Back-diffraction.
Get PDFThe linear thermal expansion coefficient of diamond has been measured using forward-diffracted profiles in X-ray backscattering. This experimental technique is presented as an alternative way of measuring thermal expansion coefficients of solids in the high-resolution Bragg backscattering geometry without the intrinsic difficulty of detecting the reflected beam. The temperature dependence of the lattice parameter is obtained from the high sensitivity of the transmitted profiles to the Bragg angle variation with temperature. The large angular width of the backscattering profiles allows the application of this technique to mosaic crystals with high resolution. As an application of this technique the thermal expansion coefficient of a synthetic type-Ib diamond (110) single crystal was measured from 10 to 300 K. Extremely low values (of the order of 1 x 10(-7) +/- 5 x 10(-7)) for the linear thermal expansion coefficient in the temperature range from 30 to 90 K are in good agreement with other reported measurements.12349-5
Healthy Body Healthy Mind: Trialling an exercise intervention for reducing depression in youth with major depressive disorder
Get PDFIntroduction: Major Depressive Disorder (MDD) has high prevalence among adolescents and young adults but evidence of any effective treatments is limited. Exercise as an effective treatment for adults has some support but studies in younger populations are lacking. MDD is associated with inflammation and exercise may contribute to reductions in inflammatory marker levels. Therefore the aim of this study was to investigate the feasibility and preliminary efficacy of brief motivational interviewing (MI) plus 12-weeks exercise training as a treatment for MDD in youth.
Methods: Youth (15-25 years) with MDD were recruited to participate in a prospective trial investigating exercise as treatment for MDD. Twenty-six participants were screened (telephone then clinical psychology diagnosis) and 13 (9 females) were eligible (MDD from SCID, no psychotic illness, not pregnant, no physical barriers to exercise, not suicidal, no major eating disorder) to participate. Participants completed assessments at baseline and after 12 weeks training, which included questionnaires: the Beck Depression Inventory (BDI-II); blood samples for analysis of inflammatory biomarkers; and fitness measures: VO2max, YMCA bench press test, and a seated horizontal leg press endurance test. Prior to commencing the training program, participants engaged in a motivational interview with a psychologist to enhance engagement with the program. IL-6 was measured by ELISA. The exercise program consisted of small group trainer-led supervised exercise (resistance and endurance) training 3 times a week (1h per session) for 12 weeks, and encouragement to do at least 30min of physical activity on other days. Paired t-tests were used to determine changes from baseline and correlations used to explore relationships between changes in depression scores, training attendance and fitness levels.
Results: 12 participants (mean±SD, aged 20.7±1.7 y) completed 12-week assessments; one withdrew due to family issues. Attendance at training averaged 66±25% of sessions; 3 participants completed less than 40% of training sessions. At baseline all participants met the criteria for MDD; at 12 weeks only 2 still met the criteria; depression severity (BDI-II) decreased (p\u3c0.001) from 32±9 to12±10. Aerobic fitness levels did not change with training. YMCA bench press repetitions increased (p\u3c0.001) from 20±11 to 27±11. IL-6 decreased (p\u3c0.05) from 1.39±0.78 to 0.73±0.80 pg.mL-1.
Changes in depression symptom scores were significantly correlated (p\u3c0.05) with attendance (r=0.32), improvements in bench press endurance (r=0.65) and changes in IL-6 (r=0.34). Changes in IL-6 were also correlated with attendance (r=0.60)
Conclusion: Exercise training is a feasible and potentially effective intervention for MDD in youth and reductions in depression severity are associated with reductions in IL-6
Embedding social inclusiveness and appropriateness in engineering assessment of green infrastructure to enhance urban resilience
Get PDFUrban resilience emerges not only from ‘what’ is done in relation to critical infrastructure systems, but in the ‘how’ of their conception, co-creation and integration into complex socio-ecological-technical systems. For green infrastructure, where ownership and agency may be distributed amongst organisations and diverse communities, inclusiveness and appropriateness require embedding in engineering assessments of green infrastructure and resilience. Through consideration of past, present and future engineering and resilience assessments – from monetising, through greening, to humanising – this paper examines the ways in which GI may be or has already contributed to enhancing urban resilience and types of assessment and indicators that have been or could be used. We suggest that enhancing visibility of the ‘whos’ (individuals, communities) is crucial to fully diversifying assessments. We also suggest some ideas for additional indicators and assert that co-production of future indicators needs to be undertaken with appropriate professionals (e.g. social impact assessment professionals)
Growth and ecophysiology of two Antarctic benthic predators; Isotealia antarctica and Urticinopsis antarctica
Get PDFThere is a dearth of basic life history and physiological data from Southern Ocean species, particularly from benthic vagile predators. This is an important data gap because species inhabiting the Southern Ocean live in a more temperature stable but seasonally varying environment than temperate and tropical counterparts. For many species living below 0 ◦C for a significant proportion of the year, bodily functions are slowed to disproportionately lower rates than would be predicted by temperature alone. Certain life history and physiological processes are often aligned with the short summer season of productivity. However, predators may behave differently because they are decoupled from the phytoplankton bloom and some have been shown to exhibit less
seasonal physiological change. To further our understanding of Antarctic predator growth and seasonal ecophysiology, field growth rates were measured for two soft-bodied Antarctic anemone benthic predators, Isotealia antarctica and Urticinopsis antarctica, using in situ sampling of anemones on uniquely marked tiles. Ex situ measurements of oxygen consumption and seven-day faecal output were obtained from recently collected specimens in aquaria and compared between summer and winter. Winter physiological data for Antarctic species are rare, and we tested the hypothesis that generalist feeders or predators continue to feed during the winter. Growth rates differed between species and between years. I. antarctica and U. antarctica both exhibited overall positive field growth rates across a 15 month period between 2020 and 2021; with U. antarctica increasing 199.80% (± SE 25.8) in mass compared to a 16.85% (± SE 8.9) increase in I. antarctica. There was no significant difference in I. antarctica’s growth between 15 and 25 months field deployment. After 25 months, I. antarctica showed an average 7.96% (± SE 8.05) increase in buoyant weight. Ex situ oxygen consumption and faecal egestion did not differ seasonally, which, demonstrates that anemones fed at similar rates during the winter and summer. In contrast to some members of the Antarctica benthos, I. antarctica and U. antarctica actively feed all year round, whereas several other species have been reported to enter a state of torpor in winter
The role of serum procalcitonin in establishing the diagnosis and prognosis of pleural infection
Get PDFBACKGROUND: Bacterial pleural infection requires prompt identification to enable appropriate investigation and treatment. In contrast to commonly used biomarkers such as C-reactive protein (CRP) and white cell count (WCC), which can be raised due to non-infective inflammatory processes, procalcitonin (PCT) has been proposed as a specific biomarker of bacterial infection. The utility of PCT in this role is yet to be validated in a large prospective trial. This study aimed to identify whether serum PCT is superior to CRP and WCC in establishing the diagnosis of bacterial pleural infection. METHODS: Consecutive patients presenting to a tertiary pleural service between 2008 and 2013 were recruited to a well-established pleural disease study. Consent was obtained to store pleural fluid and relevant clinical information. Serum CRP, WCC and PCT were measured. A diagnosis was agreed upon by two independent consultants after a minimum of 12 months. The study was performed and reported according to the STARD reporting guidelines. RESULTS: 80/425 patients enrolled in the trial had a unilateral pleural effusion secondary to infection. 10/80 (12.5%) patients had positive pleural fluid microbiology. Investigations for viral causes of effusion were not performed. ROC curve analysis of 425 adult patients with unilateral undiagnosed pleural effusions showed no statistically significant difference in the diagnostic utility of PCT (AUC 0.77), WCC (AUC 0.77) or CRP (AUC 0.85) for the identification of bacterial pleural infection. Serum procalcitonin >0.085 μg/l has a sensitivity, specificity, negative predictive value and positive predictive value of 0.69, 0.80, 0.46 and 0.91 respectively for the identification of pleural infection. The diagnostic utility of procalcitonin was not affected by prior antibiotic use (p = 0.80). CONCLUSIONS: The study presents evidence that serum procalcitonin is not superior to CRP and WCC for the diagnosis of bacterial pleural infection. The study suggests routine procalcitonin testing in all patients with unilateral pleural effusion is not beneficial however further investigation may identify specific patient subsets that may benefit. TRIAL REGISTRATION: The trial was registered with the UK Clinical Research Network (UKCRN ID 8960). The trial was approved by the South West Regional Ethics Committee (Ethical approval number 08/H0102/11). ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12931-017-0501-5) contains supplementary material, which is available to authorized users
INHIBITING CSF1R ALLEVIATES CEREBROVASCULAR WHITE MATTER DISEASE AND COGNITIVE IMPAIRMENT
Get PDFWhite matter abnormalities, related to poor cerebral perfusion, are a core feature of small vessel cerebrovascular disease, and critical determinants of vascular cognitive impairment and dementia. Despite this importance there is a lack of treatment options. Proliferation of microglia producing an expanded, reactive population and associated neuroinflammatory alterations have been implicated in the onset and progression of cerebrovascular white matter disease, in patients and in animal models, suggesting that targeting microglial proliferation may exert protection. Colony-stimulating factor-1 receptor (CSF1R) is a key regulator of microglial proliferation. We found that the expression of CSF1R/Csf1r and other markers indicative of increased microglial abundance are significantly elevated in damaged white matter in human cerebrovascular disease and in a clinically relevant mouse model of chronic cerebral hypoperfusion and vascular cognitive impairment. Using the mouse model, we investigated long-term pharmacological CSF1R inhibition, via GW2580, and demonstrated that the expansion of microglial numbers in chronic hypoperfused white matter is prevented. Transcriptomic analysis of hypoperfused white matter tissue showed enrichment of microglial and inflammatory gene sets, including phagocytic genes that were the predominant expression modules modified by CSF1R inhibition. Further, CSF1R inhibition attenuated hypoperfusion-induced white matter pathology and rescued spatial learning impairments and to a lesser extent cognitive flexibility. Overall, this work suggests that inhibition of CSF1R and microglial proliferation mediates protection against chronic cerebrovascular white matter pathology and cognitive deficits. Our study nominates CSF1R as a target for the treatment of vascular cognitive disorders with broader implications for treatment of other chronic white matter diseases.<br/
Challenges of mainstreaming green infrastructure in built environment professions
Get PDF© 2019, © 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. Green infrastructure (GI) has been identified as a promising approach to help cities adapt to climate change through the provision of multiple ecosystem services. However, GI contributions to urban resilience will not be realized until it is more fully mainstreamed in the built environment and design professions. Here, we interrogate five key challenges for the effective implementation of GI: (1) design standards; (2) regulatory pathways; (3) socio-economic considerations; (4) financeability; and (5) innovation. Methods include a literature review, case studies, and interviews with resilience managers. We propose a people-centred and context-dependent approach to advance effective implementation of GI in urban planning. We highlight two underlying currents that run across all of the challenges–(1) the role of political will as a pre-condition for tackling all challenges holistically; and (2) the role of stakeholder engagement in achieving public support, harnessing funding, and maintaining and monitoring GI in the long term. Highlights: • The effective implementation of GI is context-specific and should adhere to the basic principles of appropriate technology. • Continuous community engagement is needed to ensure the inclusivity and multi-functionality of GI. • Challenges to successful GI are intersectional and therefore cannot be addressed singly in isolation
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