49 research outputs found
The structure and the development of yew-tree population Tcixus baccala L. of different ages and of natural origin in the North-Western Poland
Get PDFSpontaneous renewing of the yew in Poland takes place
basically on the way of endozoochory. The richest stand in Poland amounting
loover 5 thousand yew trees can be found in Goleniowska Wildwood near
Szczecin. Habitat conditions have been examined there and the perennial
sampling plots established. The entire, population has been listed, height
of all yew trees on the sampling plots measured, and variability of their
habit as well as the present state of wholesomeness examined. Postulates
concerning active protection of the yew tree in Poland have been put
forward (summary see page 191).Zadanie pt. Digitalizacja i udostępnienie w Cyfrowym Repozytorium Uniwersytetu Łódzkiego kolekcji czasopism naukowych wydawanych przez Uniwersytet Łódzki nr 885/P-DUN/2014 zostało dofinansowane ze środków MNiSW w ramach działalności upowszechniającej naukę
Autologous platelet-rich plasma therapy — a promising method for tissue repair/ /regeneration in many medical fields
Get PDFPlatelet-rich plasma (PRP) is commonly used in many medicinal fields and the interest in its application for management of numerous pathologies is recently growing. Platelets (PLT) contain physiologically active proteins called growth factors (GFs) that accelerate tissue regeneration. This process of tissue regeneration is stimulated through application of PRP prepared from autologous blood according to special protocol. The purpose of the protocol is to achieve high concentration of platelets within a small volume of plasma. PRP is a biological product with a platelet concentration above the baseline for the patient’s peripheral blood. The PRP therapy is based on autologous procedures therefore the risk of infection is remote although some clinical conditions preclude the use of PRP as it may induce adverse reactions. The procedure of PRP preparation is relatively inexpensive and can be performed quickly in the patient’s presence.
In the literature of the subject there are wide variations in PRP definitions with reference to protocols of preparation, platelet concentration and activation as well as in the manner of application to injured tissue and finally in the assessment of therapy outcome. It is therefore difficult to compare and confirm the efficacy of PRP therapy used for the management of various diseases. Authors clearly emphasize the urgent need for standardizing protocols of PRP preparation and application in various disorders. Although in general PRP therapy is considered a promising method for treatment of tissue injuries, the lack of standardized preparation procedures and ways of PRP application raises numerous questions and controversies.
The aim was to present review of literature related to the use of PRP and the mechanism of action of this blood derivative
Terapia autologicznym osoczem bogatopłytkowym (PRP) — obiecująca metoda leczenia regeneracyjnego uszkodzonych tkanek stosowana w wielu dziedzinach medycyny
Get PDFPlatelet-rich plasma (PRP) therapy is widely used in many fields of medicine and is becoming more and more popular in the treatment of many diseases. Platelets (PLT) contain physiologically active proteins called growth factors (GFs) that accelerate the regeneration of damaged tissue. Stimulation of regeneration of damaged tissue is possible thanks to the use of patient's own blood, which must be properly prepared before administration. PRP preparation consists in concentrating the PLT several times in relation to the patient's peripheral blood. Because the treatment is based on autologous transfusion, the risk of adverse reactions is negligible, although in some situations some risk factors limit the use of PRP and may contribute to the occurrence of adverse effects. Preparation is relatively cheap and quick and can be carried out in the presence of a patient.
In the literature can be found different definitions of PRP, methods of preparation, concentrations of PLT, ways of activating PLT, ways of administering PRP to damaged tissue, and finally different effects of treatment with this blood derivative. In addition, confirming the effectiveness of PRP therapy is difficult, comparing the treatment of various diseases with each other. The authors clearly emphasize the need for standardization of preparation and administration of PRP in various diseases. The lack of harmonization of preparation procedures and the way of administering PRP raises many questions and controversies, although PRP therapy is considered a promising method of treating tissue injuries.
The aim of this article is to show what lies behind the concept of PRP, what is its mechanism of action as well as to show and systematize the complexity of PRP issues.Terapia osoczem bogatopłytkowym (PRP) jest powszechnie stosowana w wielu dziedzinach medycyny i zyskuje coraz większą popularność w leczeniu licznych schorzeń. Płytki krwi zawierają fizjologicznie aktywne białka, zwane czynnikami wzrostu (GFs), które przyspieszają regenerację uszkodzonej tkanki. Stymulowanie regeneracji uszkodzonej tkanki jest możliwe dzięki zastosowaniu własnej krwi pacjenta, która musi przed podaniem zostać poddana odpowiedniej preparatyce. Preparatyka PRP polega na kilkakrotnym zagęszczeniu krwinek płytkowych w porównaniu z ich stężeniem w krwi obwodowej pacjenta. Ze względu na to, że leczenie opiera się na wykonywaniu zabiegów autologicznych, ryzyko zakażenia pacjenta jest znikome, jakkolwiek w pewnych sytuacjach niektóre czynniki ryzyka ograniczają stosowanie PRP i mogą się przyczynić do wystąpienia objawów niepożądanych. Preparatyka jest stosunkowo tania i szybka, i może być przeprowadzana w obecności pacjenta.
W literaturze przedmiotu można spotkać zarówno różne definicje PRP, uwzględniające zróżnicowane sposoby preparatyki, zagęszczania i aktywacji krwinek płytkowych, jak i różne sposoby ich aplikacji do uszkodzonej tkanki i wreszcie różne efekty leczenia tym preparatem. Jednocześnie potwierdzenie skuteczności terapii PRP jest trudne, jeśli porównuje się ze sobą leczenie różnych chorób. Autorzy jednoznacznie podkreślają potrzebę standaryzacji preparatyki i określenia sposobu aplikacji w zależności od jednostki chorobowej. Brak ujednolicenia procedur preparatyki i sposobu podawania PRP rodzi wiele pytań i kontrowersji, jednak terapia PRP uważana jest za obiecującą metodę leczenia.
Celem tej pracy jest analiza piśmiennictwa dotyczącego zastosowania osocza bogatopłytkowego, z uwzględnieniem mechanizmu jego działania
Infection exposure, detection and causes of death in perinatal mortalities in Polish dairy herds
Get PDFpeer-reviewedThe objective of this study was to determine the prevalence and types of infections in perinatal mortality (PM) cases from Polish dairy farms and the relevance of the presence of infection to the cause of death. This prospective longitudinal study was carried out on 121 PM and 21 control calves with a gestation of ≥260 days. Six control calves were euthanized and examined using the same protocol as for PM calves. Material was collected over a 20-month period between November 2013 and June 2015. The PM and control calves were collected from 29 to 5 herds, respectively.
Blood samples from calves were tested for antibodies to Neospora caninum, glycoprotein B of BoHV-1, BVDV and SBV using ELISAs and Leptospira hardjo and Leptospira pomona with the microscopic agglutination test. Brain and kidney samples from all PM and six euthanized control calves were tested using real time PCR to detect Neospora caninum, pathogenic Leptospira spp., BoHV-1 and SBV; brain was examined histopathologically for detection of N. caninum cysts. Samples from eight inner organs from all PM and six control calves were cultured aerobically, anaerobically and microaerobically. Ear samples from all PM and control calves were tested for BVDV using an antigen ELISA.
In total, 21.5% of PM calves were infected (antigen and/or antibody-positive) in utero; none of the control calves were infected. Direct evidence of infection (culture, Ag-ELISA, PCR, histopathology) was detected in 9.1% of PM calves. Gestation length in infected singletons was shorter than in uninfected singletons (274 ± 8 vs. 279 ± 7 days; P < 0.01). The odds ratio for diagnosis of infection in single pregnancies ≤275 days was 3.75 (95% CI:1.2–12.1), (P < 0.05). Infection was the cause of death in 10% of calves. The most common infections detected in these Polish PM calves were parasitic (11.6% of PM cases), viral (7.4%) and bacterial (5%). This study demonstrated that indirect evidence of infection is detected more frequently than direct, coinfection is rare, infection is rarely accompanied by gross lesions and is rarely a cause of death in cases of PM
Comparison of phase structures and surface free energy values for the coatings synthesised from linear polyurethanes and from waterborne polyurethane cationomers
Get PDFWAXS, DSC and AFM methods were employed to compare phase structures of the coatings obtained from waterborne polyurethane cationomers which had been synthesised in the reaction of some diisocyanates (MDI, IPDI, TDI and HDI) with polyoxyethylene glycols (M = 600 and 2,000) and butane1,4-diol or N-methyl- or N-butyldiethanolamine and 2,2,3,3-tetrafluoro-1,4-butanediol. The structures were also analysed of the coatings derived from linear polyurethanes which had been synthesised on the basis of similar raw materials. Better rigidity was found for generally amorphous cationomer coats. Changes were discussed in the surface free energy (SFE) values and in their components, as calculated independently with the use of the van Oss–Good and Owens–Wendt methods. Polyurethane coats turned out more hydrophobic as compared to cationomer ones. In both coat types, fluorine incorporated into cationomers contributed to lower SFE values: from 50 down to about 30 mJ/m2
Winter severity and anthropogenic factors affect spatial behaviour of red deer in the Carpathians
Get PDFSynthesis and characterisation of coating polyurethane cationomers containing fluorine built-in hard urethane segments
Get PDFPolyurethane cationomers were synthesised in the reaction of 4,4’-methylenebis(phenyl isocyanate) with polyoxyethylene glycol (M = 2,000) or poly(tetrafluoroethyleneoxide-co-difluoromethylene oxide) α,ω-diisocyanate and N-methyl diethanolamine. Amine segments were built-in to the urethane-isocyanate prepolymer in the reaction with 1-bromobutane or formic acid, and then they were converted to alkylammonium cations. The obtained isocyanate prepolymers were then extended in the aqueous medium that yielded stable aqueous dispersions which were applied on the surfaces of test poly(tetrafluoroethylene) plates. After evaporation of water, the dispersions formed thin polymer coatings. 1H, 13C NMR and IR spectral methods were employed to confirm chemical structures of synthesised cationomers. Based on 1H NMR and IR spectra, the factors κ and α were calculated, which represented the polarity level of the obtained cationomers. The DSC, wide angle X-ray scattering and atom force microscopy methods were employed for the microstructural assessment of the obtained materials. Changes were discussed in the surface free energy and its components, as calculated independently according to the method suggested by van Oss–Good, in relation to chemical and physical structures of cationomers as well as morphology of coating surfaces obtained from those cationomers. Fluorine incorporated into cationomers (about 30%) contributed to lower surface free energy values, down to about 15 mJ/m2. That was caused by gradual weakening of long-range interactions within which the highest share is taken by dispersion interactions
Can Recurrence Quantification Analysis Be Useful in the Interpretation of Airborne Turbulence Measurements?
Get PDFIn airborne data or model outputs, clouds are often defined using information about Liquid Water Content (LWC). Unfortunately LWC is not enough to retrieve information about the dynamical boundary of the cloud, that is, volume of turbulent air around the cloud. In this work, we propose an algorithmic approach to this problem based on a method used in time series analysis of dynamical systems, namely Recurrence Plot (RP) and Recurrence Quantification Analysis (RQA). We construct RPs using time series of turbulence kinetic energy, vertical velocity and temperature fluctuations as variables important for cloud dynamics. Then, by studying time series of laminarity (LAM), a variable which is calculated using RPs, we distinguish between turbulent and non-turbulent segments along a horizontal flight leg. By selecting a single threshold of this quantity, we are able to reduce the number of subjective variables and their thresholds used in the definition of the dynamical cloud boundary
Comparison of reorganized versus unaltered cardiology departments during the COVID-19 era: a subanalysis of the COV-HF-SIRIO 6 study
Get PDFBackground: Since the beginning of the coronavirus disease-2019 (COVID-19) pandemic, numerous cardiology departments were reorganized to provide care for COVID-19 patients. We aimed to compare the impact of the COVID-19 pandemic on hospital admissions and in-hospital mortality in reorganized vs. unaltered cardiology departments. Methods: The present subanalysis is a multicenter retrospective COV-HF-SIRIO 6 study that includes all patients (n = 101,433) hospitalized in 24 cardiology departments in Poland between January 1, 2019 and December 31, 2020, with a focus on patients with acute heart failure (AHF). Results: Reduction of all-cause hospitalizations was 50.6% vs. 21.3% for reorganized vs. unaltered cardiology departments in 2020 vs. 2019, respectively (p < 0.0001). Considering AHF alone respective reductions by 46.5% and 15.2% were registered (p < 0.0001). A higher percentage of patients was brought in by ambulance to reorganized vs. unaltered cardiology departments (51.7% vs. 34.6%; p < 0.0001) alongside with a lower rate of self-referrals (45.7% vs. 58.4%; p < 0.0001). The rate of all-cause in-hospital mortality in AHF patients was higher in reorganized than unaltered cardiology departments (10.9% vs. 6.4%; p < 0.0001). After the exclusion of patients with concomitant COVID-19, the mortality rates did not differ significantly (6.9% vs. 6.4%; p = 0.55). Conclusions: In cardiology departments reorganized to provide care for COVID-19 patients vs. unaltered ones, observed: i) a greater reduction in hospital admissions in 2020 vs. 2019; ii) higher rates of patients brought by ambulance and lower rates of self-referrals; and iii) higher all-cause in-hospital mortality for AHF due to COVID-19 related deaths
